Diagnostic Challenge & Standing Clinical Hypothesis

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This page outlines the comprehensive working diagnosis of Nicole Henry, developed by her primary advocate and based on five years of independent medical investigation, review of hospital records, imaging, lab data, and firsthand testimony.

The following diagnosis is presented as a Standing Open Diagnostic Review Challenge. Any licensed medical professional, academic physician, or credentialed clinical researcher is welcome to provide a detailed, evidence-based rebuttal.

We do not fear being proven wrong. We fear truth being ignored.

Primary Diagnoses (Working Hypothesis):

• Drug-Induced Liver Injury (DILI) initiated in August 2019 by the combination of Effexor and inappropriate NPO status, rendering the liver vulnerable and setting off a chain of systemic complications.
   
• Bile Duct Injury and Chronic Bile Reflux following the September 3, 2019 ERCP, with suspected improper stent placement. This led to persistent bile vomiting and progressive liver enlargement.
   
• Right-Sided Cardiac Injury resulting from 2 separate lipid emboli hours after the ERCP — evidenced by an elevated right atrial pressure (15 mmHg) and inferior vena cava (IVC) dilation measuring 2.57 cm.
   
• Undiagnosed Hepatic Encephalopathy, including an unrecorded hepatic coma from December 5–8, 2019. This was triggered by the administration of valproic acid despite known liver compromise and a positive ASMA (autoimmune marker).
   
• Hormonally Active Adrenocortical Carcinoma (ACC) located on the medial limb of the left adrenal gland. The tumor demonstrates malignant growth behavior and is supported by an aldosterone/renin ratio >40, suppressed morning cortisol, and serial imaging. Ongoing hormonal dysfunction has contributed to significant mitral valve stenosis — with the valve area decreasing by approximately 35% (from 4.13 cm² in February 2019 to 2.57 cm² by November 2024).

We invite licensed clinicians to review the timeline and submit:

• A full alternative diagnosis or explanation
• Supporting evidence from Nicole’s available records (available upon request)
• A scientific rationale for rejecting our hypothesis
• "Because I am a doctor."  Does not count as reasoning.

To Submit: Email your response to: admin@maliceinmedicine.com Include credentials and institutional affiliation. Anonymous or unsupported feedback will not be considered.

Nicole Henry is still alive. Still fighting. And she deserves more than closed doors and defensive silence.

We are not issuing this challenge to prove anyone wrong. We are issuing it because being right about this has only led to doors being shut. This challenge is for the sake of every patient whose symptoms were explained away, every woman told it was "just anxiety," and every family who knew something was wrong long before the chart ever admitted it.

If we are wrong, prove it. If we are right, do something about it.

Step into The Gauntlet — the master timeline that lays it all bare.
Every record. Every contradiction. Every silence, dated and timestamped.

👉 [Enter The Gauntlet]